Western Governors University (WGU) NURS6800 D116 Advanced Pharmacology for the Advanced Practice Nurse Practice Exam

This translocation creates the Philadelphia chromosome by fusing the BCR gene on chromosome 22 with the ABL1 gene on chromosome 9, resulting in the BCR-ABL fusion. That fusion produces a constitutively active tyrosine kinase that drives uncontrolled cell growth, a hallmark of chronic myeloid leukemia and a key target for tyrosine kinase inhibitors like imatinib. The other translocations involve different genes and drive other cancers (for example, 8;14 with c-MYC in Burkitt lymphoma, 11;14 with cyclin D1 in mantle cell lymphoma, and 15;17 with PML-RARA in acute promyelocytic leukemia).